James Cook Week 5 Preview vs. the Patriots

James Cook will be up against the second-best run defense in the league when his Buffalo Bills play the New England Patriots in Week 5, on Sunday at 8:20 p.m. ET.

Cook, on 75 carries, has a team-leading 401 rushing yards (100.3 ypg). He has scored five TDs on the ground. Cook has also reeled in 12 passes for 89 yards (22.3 ypg).

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Cook vs. the Patriots

• Cook vs the Patriots (since 2021): 2 GP / 64 RUSH YPG / 2 RUSH TD
• No player has put up more than 100 yards on the ground in a game against the Patriots in the 2025 season.
• Two opposing rushers have scored at least one touchdown on the ground against New England this year.
• The Patriots have not allowed any opposing players to record two or more rushing TDs against them this season.
• The 77.5 rushing yards per game conceded by the Patriots defense makes them the NFL's second-ranked run defense.
• The Patriots have the No. 3 defense in the NFL in rushing TDs allowed, conceding two this season (0.5 per game).

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Cook Rushing Insights

• Cook has hit his rushing yards over in 75.0% of his opportunities (three of four games).
• The Bills have passed 48.0% of the time and run 52.0% this season. They rank fifth in the NFL in scoring.
• His team has attempted 133 rushes this season. He's handled 75 of those carries (56.4%).
• Cook has rushing touchdowns in all four games this year, including multiple TDs once.
• He has five total touchdowns this season (31.2% of his team's 16 offensive TDs).
• He has 17 red zone carries for 58.6% of the team share (his team runs on 58% of its plays in the red zone).

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Cook's Recent Performance