Pitt vs. Syracuse Football Prediction & Odds - Oct. 18

Pittsburgh v West Virginia

Photo: Brien Aho / Getty Images Sport / Getty Images

The Pittsburgh Panthers (4-2) meet a fellow ACC opponent when they visit the Syracuse Orange (3-3) on Saturday, October 18, 2025 at the JMA Wireless Dome.

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Pittsburgh vs. Syracuse Matchup Info

  • Game date: Saturday, October 18, 2025
  • Game time: 7:30 p.m. ET
  • Location: Syracuse, New York
  • Venue: JMA Wireless Dome
  • TV channel: ACC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Pittsburgh vs. Syracuse Odds and Prediction

  • Spread favorite: Panthers (-9.5)
  • Moneyline: Panthers (-375), Orange (+292)
  • Total: 54.5 points
  • Pick ATS: Pittsburgh (-9.5)
  • Pick OU: Over (54.5)
  • Prediction: Pittsburgh 34, Syracuse 22

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Pittsburgh vs. Syracuse Betting Records and Insights

  • Pittsburgh has compiled a 4-2-0 ATS record so far this year.
  • Syracuse has compiled a 3-2-1 ATS record so far this season.
  • The Panthers have won each of their two games this season when playing as at least 9.5-point favorites.
  • The Orange have covered the spread twice this year (2-1 ATS) when playing as at least 9.5-point underdogs.
  • So far this season, four of Pittsburgh's six games have gone over the point total.
  • Syracuse games have hit the over three out of six times this year.

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