The Syracuse Orange (3-7) visit the No. 9 Notre Dame Fighting Irish (8-2) at Notre Dame Stadium on Saturday, November 22, 2025.
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Notre Dame vs. Syracuse Matchup Info
- Game date: Saturday, November 22, 2025
- Game time: 3:30 p.m. ET
- Location: South Bend, Indiana
- Venue: Notre Dame Stadium
- TV channel: NBC
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Notre Dame vs. Syracuse Odds and Prediction
- Spread favorite: Fighting Irish (-36.5)
- Moneyline: Fighting Irish (), Orange ()
- Total: 50.5 points
- Pick ATS: Notre Dame (-36.5)
- Pick OU: Over (50.5)
- Prediction: Notre Dame 46, Syracuse 8
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Notre Dame vs. Syracuse Betting Records and Insights
- Notre Dame has put together a 5-5-0 record against the spread this season.
- Syracuse has covered four times in 10 chances against the spread this season.
- In Notre Dame's 10 games this season, the combined scoring has gone over the point total five times.
- In Syracuse's 10 contests this year, the combined scoring has gone over the point total five times.